Basic Information

Symbol
TRPM2
RNA class
mRNA
Alias
Transient Receptor Potential Cation Channel Subfamily M Member 2 LTRPC2 EREG1 KNP3 NUDT9L1 NUDT9H TRPC7 Estrogen-Responsive Element-Associated Gene 1 Protein Long Transient Receptor Potential Channel 2 Transient Receptor Potential Melastatin 2 Transient Receptor Potential Channel 7 LTrpC-2 Transient Receptor Potential Cation Channel, Subfamily M, Member 2 LTrpC2 TrpC7
Location (GRCh38)
21:44350072-44445246
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003307.4
Sequence length
5419.0 nt
GC content
0.6167

Transcripts

ID Sequence Length GC content
NM_001320350.2 NCBI
AGAACCCCAGUGUAGCGAGCUGGAGAGAGGACUGUCCUGAGGGCAGCAG… 5569 nt 0.6154
NM_001320351.2 NCBI
AGAACCCCAGUGUAGCGAGCUGGAGAGAGGACUGUCCUGAGGGCAGCAG… 5317 nt 0.6158
NM_001320352.3 NCBI
GUCUUCCUGACUGUCCCCAGCCUCCCAGAAGGCCGCGGAGGAGCCGGAU… 1580 nt 0.6361
NM_003307.4 NCBI
AGAACCCCAGUGUAGCGAGCUGGAGAGAGGACUGUCCUGAGGGCAGCAG… 5419 nt 0.6167
Summary

The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

Forensic Context

No relevant information is available at the moment.