Basic Information

Symbol
TRPM3
RNA class
mRNA
Alias
Transient Receptor Potential Cation Channel Subfamily M Member 3 LTRPC3 KIAA1616 GON-2 Long Transient Receptor Potential Channel 3 Melastatin-2 MLSN2 Transient Receptor Potential Cation Channel, Subfamily M, Member 3 Melastatin 2 EC 5.99.1.3 EC 2.3.1.31 CTRCT50 LTrpC-3 NEDFSS LTrpC3
Location (GRCh38)
9:70529060-71446977
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001366145.2
Sequence length
12320.0 nt
GC content
0.4334

Transcripts

ID Sequence Length GC content
NM_001007470.3 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 1358 nt 0.4742
NM_001007471.4 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 12284 nt 0.4334
NM_001366141.2 NCBI
GCUCUGGCAGGAGCCGGCGGAGGCAAAGGCAGCGCCAACCGAGAGCCGC… 12159 nt 0.4368
NM_001366142.2 NCBI
GCUCUGGCAGGAGCCGGCGGAGGCAAAGGCAGCGCCAACCGAGAGCCGC… 10525 nt 0.4282
NM_001366143.2 NCBI
GCUCUGGCAGGAGCCGGCGGAGGCAAAGGCAGCGCCAACCGAGAGCCGC… 10489 nt 0.4283
NM_001366144.2 NCBI
GCUCUGGCAGGAGCCGGCGGAGGCAAAGGCAGCGCCAACCGAGAGCCGC… 1535 nt 0.5192
NM_001366145.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 12320 nt 0.4334
NM_001366146.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 10650 nt 0.4244
NM_001366147.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 12395 nt 0.4335
NM_001366148.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 10695 nt 0.4243
Showing 1 to 10 of 23 entries
Summary

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the TRPM3 was down-regulated in kidney tissue at 8 and 24 hours after whole-body irradiation with 10 Gy γ-rays, showing fold changes of 0.502 and 0.529, respectively [Zhao et al. DOI:10.1158/1078-0432.CCR-05-2418]. In human forensic research, ATAC-seq analysis of postmortem brain tissue from traumatic brain injury (TBI) cases showed marked increases in chromatin accessibility for the TRPM3 in the TBI group compared to controls, with these epigenetic changes remaining stable and detectable even after 24 hours of controlled degradation [Xu et al. DOI:10.1016/J.Forsciint.2025.112789].