Basic Information

Symbol
TRPM3
RNA class
mRNA
Alias
Transient Receptor Potential Cation Channel Subfamily M Member 3 LTRPC3 KIAA1616 GON-2 Long Transient Receptor Potential Channel 3 Melastatin-2 MLSN2 Transient Receptor Potential Cation Channel, Subfamily M, Member 3 Melastatin 2 EC 5.99.1.3 EC 2.3.1.31 CTRCT50 LTrpC-3 NEDFSS LTrpC3
Location (GRCh38)
9:70529060-71446977
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001366145.2
Sequence length
12320.0 nt
GC content
0.4334

Transcripts

ID Sequence Length GC content
NM_001366149.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 12290 nt 0.4331
NM_001366150.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 10584 nt 0.4241
NM_001366151.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 10614 nt 0.4244
NM_001366152.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 10725 nt 0.4246
NM_001366153.2 NCBI
AUUCUGGAGCAGGCUGCUUUGACUCCGACCACAGGCUGUUUUGUGCAGG… 1660 nt 0.4880
NM_001366154.2 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 10273 nt 0.4205
NM_020952.6 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 11907 nt 0.4303
NM_024971.7 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 11943 nt 0.4303
NM_206944.5 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 11877 nt 0.4301
NM_206945.5 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 11913 nt 0.4300
Showing 11 to 20 of 23 entries
Summary

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the TRPM3 was down-regulated in kidney tissue at 8 and 24 hours after whole-body irradiation with 10 Gy γ-rays, showing fold changes of 0.502 and 0.529, respectively [Zhao et al. DOI:10.1158/1078-0432.CCR-05-2418]. In human forensic research, ATAC-seq analysis of postmortem brain tissue from traumatic brain injury (TBI) cases showed marked increases in chromatin accessibility for the TRPM3 in the TBI group compared to controls, with these epigenetic changes remaining stable and detectable even after 24 hours of controlled degradation [Xu et al. DOI:10.1016/J.Forsciint.2025.112789].