Basic Information

Symbol
TRPM3
RNA class
mRNA
Alias
Transient Receptor Potential Cation Channel Subfamily M Member 3 LTRPC3 KIAA1616 GON-2 Long Transient Receptor Potential Channel 3 Melastatin-2 MLSN2 Transient Receptor Potential Cation Channel, Subfamily M, Member 3 Melastatin 2 EC 5.99.1.3 EC 2.3.1.31 CTRCT50 LTrpC-3 NEDFSS LTrpC3
Location (GRCh38)
9:70529060-71446977
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001366145.2
Sequence length
12320.0 nt
GC content
0.4334

Transcripts

ID Sequence Length GC content
NM_206946.5 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 11982 nt 0.4305
NM_206947.5 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 11952 nt 0.4302
NM_206948.4 NCBI
AGCAAAAUGAAAGCAACAGGAGCUGCUCCGGGGACUGCUUUUGCCAGUA… 1283 nt 0.4754
Showing 21 to 23 of 23 entries
Summary

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the TRPM3 was down-regulated in kidney tissue at 8 and 24 hours after whole-body irradiation with 10 Gy γ-rays, showing fold changes of 0.502 and 0.529, respectively [Zhao et al. DOI:10.1158/1078-0432.CCR-05-2418]. In human forensic research, ATAC-seq analysis of postmortem brain tissue from traumatic brain injury (TBI) cases showed marked increases in chromatin accessibility for the TRPM3 in the TBI group compared to controls, with these epigenetic changes remaining stable and detectable even after 24 hours of controlled degradation [Xu et al. DOI:10.1016/J.Forsciint.2025.112789].