Basic Information

Symbol
TRPM7
RNA class
mRNA
Alias
Transient Receptor Potential Cation Channel Subfamily M Member 7 LTRPC7 CHAK1 TRP-PLIK Long Transient Receptor Potential Channel 7 Channel-Kinase 1 EC 2.7.11.1 LTrpC-7 Transient Receptor Potential Cation Channel, Subfamily M, Member 7 Transient Receptor Potential-Phospholipase C-Interacting Kinase LTRPC Ion Channel Family Member 7 ALSPDC LTrpC7 CHAK
Location (GRCh38)
15:50552473-50686797
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_017672.6
Sequence length
10382.0 nt
GC content
0.3954

Transcripts

ID Sequence Length GC content
NM_001301212.2 NCBI
GUCCCCAGCCCCGUCGCCGGCGGAGGCGGGCGCGGGCGCGUCCCUGUGG… 10379 nt 0.3953
NM_017672.6 NCBI
GUCCCCAGCCCCGUCGCCGGCGGAGGCGGGCGCGGGCGCGUCCCUGUGG… 10382 nt 0.3954
Summary

This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]

Forensic Context

No relevant information is available at the moment.