Basic Information

Symbol
TRPV4
RNA class
mRNA
Alias
Transient Receptor Potential Cation Channel Subfamily V Member 4 OTRPC4 TRP12 VROAC VR-OAC VRL-2 CMT2C Osmosensitive Transient Receptor Potential Channel 4 Transient Receptor Potential Protein 12 Vanilloid Receptor-Like Channel 2 Osm-9-Like TRP Channel 4 VRL2 Transient Receptor Potential Cation Channel, Subfamily V, Member 4 Vanilloid Receptor-Related Osmotically Activated Channel Vanilloid Receptor-Related Osmotically-Activated Channel OSM9-Like Transient Receptor Potential Channel 4 Vanilloid Receptor-Like Protein 2 HMSN2C SSQTL1 BCYM3 SPSMA TrpV4 SMAL
Location (GRCh38)
12:109783087-109833406
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_021625.5
Sequence length
3228.0 nt
GC content
0.6047

Transcripts

ID Sequence Length GC content
NM_001177428.1 NCBI
GCUGAGCAGUGCAGACGGGCCUGGGGCAGGCAUGGCGGAUUCCAGCGAA… 3051 nt 0.5998
NM_001177431.1 NCBI
AUGGCGGAUUCCAGCGAAGGCCCCCGCGCGGGGCCCGGGGAGGUGGCUG… 3059 nt 0.5973
NM_001177433.1 NCBI
GCUGAGCAGUGCAGACGGGCCUGGGGCAGGCAUGGCGGAUUCCAGCGAA… 2871 nt 0.6015
NM_021625.5 NCBI
AUUCAGGAAGCGCGGAUCUCCCGGCCGCCGGCGCCCAGCCGUCCCGGAG… 3228 nt 0.6047
NM_147204.2 NCBI
GCUGAGCAGUGCAGACGGGCCUGGGGCAGGCAUGGCGGAUUCCAGCGAA… 3012 nt 0.6019
Summary

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Forensic Context

A study in mice demonstrated that spinal nerve ligation induced significant whole-transcriptome changes in injured dorsal root ganglia, with the TRPV4 being upregulated 1.89-fold six days post-injury [Wu et al. DOI:10.1177/1744806916629048].