Basic Information

Symbol
TSC22D3
RNA class
mRNA
Alias
TSC22 Domain Family Member 3 TSC-22R GILZ DSIPI HDIP DIP Glucocorticoid-Induced Leucine Zipper Protein Delta Sleep-Inducing Peptide Immunoreactor TSC22 Domain Family Protein 3 DSIP-Immunoreactive Peptide TSC-22-Like Protein Delta Sleep Inducing Peptide, Immunoreactor DSIP-Immunoreactive Leucine Zipper Protein Glucocorticoid-Induced Leucine Zipper TSC22 Domain Family, Member 3 TSC-22 Related Protein TSC-22-Related Protein Protein DIP
Location (GRCh38)
X:107713221-107777342
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_198057.3
Sequence length
2269.0 nt
GC content
0.5275

Transcripts

ID Sequence Length GC content
NM_001015881.2 NCBI
GUCAUCGAAGCGUCCCUGCGGCCGCUGCGCCGUGAAAACCAGCUGCUGC… 1775 nt 0.5082
NM_001318468.1 NCBI
GUCAUAUCCCAGUGCUGACUCCCGGGCGUGCAGACCGCUAACUAGCUCA… 2237 nt 0.5248
NM_001318470.1 NCBI
GUCAUAUCCCAGUGCUGACUCCCGGGCGUGCAGACCGCUAACUAGCUCA… 2223 nt 0.5254
NM_004089.4 NCBI
GAGUCUGGGUUGGACUGGCGGCCGUGGAGUUUGUGACAUACGAGGUGAC… 1954 nt 0.5113
NM_198057.3 NCBI
CUCCACAGGUCCGCCCCAAUCCCCGCUCACACUUGGGAAACUUGGGACU… 2269 nt 0.5275
Summary

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Forensic Context

No relevant information is available at the moment.