Basic Information

Symbol
TSHZ2
RNA class
mRNA
Alias
Teashirt Zinc Finger Homeobox 2 OVC10-2 TSH2 Zinc Finger Protein 218 C20orf17 ZNF218 ZABC2 Ovarian Cancer-Related Protein 10-2 Teashirt Family Zinc Finger 2 Teashirt Homolog 2 Serologically Defined Colon Cancer Antigen 33 Like Chromosome 20 Open Reading Frame 17 Cell Growth-Inhibiting Protein 7
Location (GRCh38)
20:52972358-53495330
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_173485.6
Sequence length
12236.0 nt
GC content
0.4251

Transcripts

ID Sequence Length GC content
NM_001193421.2 NCBI
AUUUAUUUUUCUAGAACACACCCGACAUGUAGGCUCUAUUGCAAUACAU… 11654 nt 0.4169
NM_173485.6 NCBI
AGUUUGUUCAGCGGGAUCGAUGUUUGCUGGCAUCGCCUCGCCCUGUCUU… 12236 nt 0.4251
Summary

This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Forensic Context

A study in humans established a targeted RNA sequencing protocol for predicting the time-of-day of bloodstain deposition using 69 candidate mRNA markers, where the TSHZ2 was excluded from the final analysis panel after initial testing due to low expression [Gosch et al. DOI:10.1101/2025.02.03.636230][Gosch et al. DOI:10.1016/J.Fsigen.2025.103287].