Basic Information

Symbol
TSPAN12
RNA class
mRNA
Alias
Tetraspanin 12 Transmembrane 4 Superfamily Member 12 TM4SF12 NET-2 Tetraspan NET-2 Tetraspanin-12 Tspan-12 NET2 EVR5
Location (GRCh38)
7:120787319-120858402
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012338.4
Sequence length
2585.0 nt
GC content
0.4023

Transcripts

ID Sequence Length GC content
NM_012338.4 NCBI
GCGCUGAGAGUUUGUGCAGCUGGCCCUGGCUGCCGCCGCUGCCUCGUCC… 2585 nt 0.4023
Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans and C57BL/6 mice identified the TSPAN12 as a potential diagnostic mRNA target for hypertrophic cardiomyopathy (HCM) through LASSO and SVM-RFE analysis of hypoxia-related differentially expressed genes [Yu et al. DOI:10.1186/s40659-023-00451-4].