Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GCCGGAGCCUGCCGCUCCCCGCGCUCGUAGCGCGGGCCUGGGGACUGGG… | 3141 nt | 0.3664 | |
| GCCGGAGCCUGCCGCUCCCCGCGCUCGUAGCGCGGGCCUGGGGACUGGG… | 3132 nt | 0.3665 | |
| GCCGGAGCCUGCCGCUCCCCGCGCUCGUAGCGCGGGCCUGGGGACUGGG… | 3216 nt | 0.3678 |
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Forensic Context
A study in humans and mice demonstrated that TSPAN2 is a component of a migrasome-related gene signature with robust diagnostic performance for acute myocardial infarction, achieving an AUC of 0.955 in a training cohort [Zhu et al. DOI:10.3390/biomedicines12071626]. In humans with erectile dysfunction, single-cell RNA sequencing revealed its expression in endothelial subclusters within cavernous tissue [Fang et al. DOI:10.3389/fendo.2022.874915]. A study in mice demonstrated that dietary methylmercury exposure in male BALB/c mice significantly altered hippocampal protein and RNA expression, with the TSPAN2 being downregulated at both the protein and RNA levels following high-dose exposure, indicating its role in oligodendrocyte differentiation is affected by neurotoxic insult [Mellingen et al. DOI:10.1093/Mtomcs/Mfab022].