Basic Information

Symbol
TSPAN4
RNA class
mRNA
Alias
Tetraspanin 4 NAG-2 Transmembrane 4 Superfamily Member 7 TETRASPAN TSPAN-4 TM4SF7 Novel Antigen 2 Tetraspanin-4 NAG2 Tetraspan TM4SF Tspan-4
Location (GRCh38)
11:840686-867120
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003271.5
Sequence length
1379.0 nt
GC content
0.6418

Transcripts

ID Sequence Length GC content
NM_001025234.2 NCBI
GAAGGGCAGGACAGGGGCCCUGAGUAACGGUGGCCUGGGGUCAGAGCCA… 1397 nt 0.6364
NM_001025235.2 NCBI
CGUGCGGCCAGGGUCCCGUGGCCGGAGGUGUCCGACCGGGAGCGGCUGG… 1420 nt 0.6430
NM_001025236.2 NCBI
CGUGCGGCCAGGGUCCCGUGGCCGGAGGUGUCCGACCGGGAGCGGCUGG… 1425 nt 0.6435
NM_001025237.2 NCBI
CCAUUUCCCAGCAGAGCCCCUGAGAUCUGGAGACUGCCCCAGCCUCAGG… 1489 nt 0.6400
NM_001025238.2 NCBI
GUGUCCGCUUGACUGACAGCUGCGCGGCGGGAGCGGGCGGCGCGAGCGG… 1279 nt 0.6403
NM_001025239.2 NCBI
GUGUCCGCUUGACUGACAGCUGCGCGGCGGGAGCGGGCGGCGCGAGCGG… 1299 nt 0.6428
NM_003271.5 NCBI
GUGUCCGCUUGACUGACAGCUGCGCGGCGGGAGCGGGCGGCGCGAGCGG… 1379 nt 0.6418
Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the TSPAN4 is abundantly expressed in migrasomes, serving as the most distinct marker for these vesicles, and is upregulated in murine models with induced acute myocardial infarction [Zhu et al. DOI:10.3390/biomedicines12071626].