Basic Information

Symbol
TSPAN5
RNA class
mRNA
Alias
Tetraspanin 5 Tspan-5 Transmembrane 4 Superfamily Member 9 TM4SF9 NET-4 Tetraspan NET-4 Tetraspanin-5 Transmembrane 4 Superfamily, Member 8 Tetraspan TM4SF NET4
Location (GRCh38)
4:98470365-98658690
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005723.4
Sequence length
3347.0 nt
GC content
0.4777

Transcripts

ID Sequence Length GC content
NM_005723.4 NCBI
AAGCGAGCGGCGUCUCCACCAGCAUCUGCCGCGGCCGCCUUUGCCCGAA… 3347 nt 0.4777
Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the TSPAN5 as a gene differentially expressed in the dorsolateral prefrontal cortex of individuals with alcohol use disorder, and its expression was found to be downregulated by the FDA-approved AUD treatment acamprosate [Willis et al. DOI:10.1038/S41380-024-02777-1].