Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GUUUCCGCUGGCGGCGGCGGCGGCGGCGGUGCCGGAGCGCGAGCAGAGC… | 4255 nt | 0.5810 | |
| GUUUCCGCUGGCGGCGGCGGCGGCGGCGGUGCCGGAGCGCGAGCAGAGC… | 4322 nt | 0.5789 |
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009]
Forensic Context
A study in rats demonstrated that the TSPAN9 was significantly upregulated in left ventricular tissues from an ischemic cardiomyopathy model created via coronary artery ligation [Wang et al. DOI:10.1007/s12031-018-1066-6]. In human studies, the TSPAN9 was identified as a component of a migrasome-related gene signature for diagnosing acute myocardial infarction, where it was upregulated in patient peripheral blood and clustered in a specific kinetic pattern during macrophage transition in a mouse model [Zhu et al. DOI:10.3390/biomedicines12071626].