Basic Information

Symbol
TSPOAP1
RNA class
mRNA
Alias
TSPO Associated Protein 1 RIM-BP1 PRAX-1 RIMBP1 KIAA0612 BZRAP1 Peripheral-Type Benzodiazepine Receptor-Associated Protein 1 Benzodiazepine Receptor (Peripheral) Associated Protein 1 Peripheral Benzodiazepine Receptor-Interacting Protein RIMS-Binding Protein 1 PBR-IP Benzodiazapine Receptor Peripheral-Associated Protein 1 TSPO-Associated Protein 1 DYT22 PRAX1 RBP1
Location (GRCh38)
17:58301228-58328795
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004758.4
Sequence length
7698.0 nt
GC content
0.6222

Transcripts

ID Sequence Length GC content
NM_001261835.2 NCBI
AAUUCUGAGGCUCAGCCCUCCUCGGAGCCCACCAUCUCGAGGCUCCUGG… 7671 nt 0.6226
NM_004758.4 NCBI
AAUUCUGAGGCUCAGCCCUCCUCGGAGCCCACCAUCUCGAGGCUCCUGG… 7698 nt 0.6222
NM_024418.3 NCBI
AAUUCUGAGGCUCAGCCCUCCUCGGAGCCCACCAUCUCGAGGCUCCUGG… 7518 nt 0.6210
Summary

Enables benzodiazepine receptor binding activity. Involved in regulation of neurotransmitter secretion. Located in mitochondrion. Implicated in dystonia 22, adult-onset and dystonia 22, juvenile-onset. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that active (contingent) MDMA self-administration, compared to passive (yoked) administration, induced specific transcriptional changes in the hippocampus, including the downregulation of the TSPOAP1 which modulates synaptic transmission [Fernandez-Castillo et al. DOI:10.1111/J.1601-183X.2011.00735.X]. A study in mice identified retinol binding protein 1 (RBP1) as a retinoic acid-related transcript with enhanced expression in the nucleus accumbens shell [Crofton et al. DOI:10.1016/J.Neuropharm.2020.108398].