Basic Information

Symbol
TST
RNA class
mRNA
Alias
Thiosulfate Sulfurtransferase RDS Thiosulfate Sulfurtransferase (Rhodanese) EC 2.8.1.1 Rhodanese Epididymis Secretory Sperm Binding Protein EC 2.8.1
Location (GRCh38)
22:37010859-37024797
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003312.6
Sequence length
1125.0 nt
GC content
0.6107

Transcripts

ID Sequence Length GC content
NM_001270483.1 NCBI
UGUCUCUUCCUGGGGCCUCUGGGUGACACGCAGAGCUGAAGCCAUGGUU… 1111 nt 0.5995
NM_003312.6 NCBI
AACUUCUCCAGCCGGCCGGGGCGAGCGCCAGCGCGGCGUCCGGGGCGAG… 1125 nt 0.6107
Summary

This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Forensic Context

A study in humans demonstrated that the TST gene was upregulated as part of the metabolism of amino acids and derivatives pathway in the colon and heart of sepsis patients compared to uninfected controls [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938].