Basic Information

Symbol
TTC36
RNA class
mRNA
Alias
Tetratricopeptide Repeat Domain 36 HBP21 Tetratricopeptide Repeat Protein 36 HSP70 Binding Protein 21 TPR Repeat Protein 36 HSP70-Binding Protein 21
Location (GRCh38)
11:118527437-118531197
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001080441.4
Sequence length
668.0 nt
GC content
0.6662

Transcripts

ID Sequence Length GC content
NM_001080441.4 NCBI
GGGAUUUUGGAGUUGAGCACCAUGGGGACUCCAAAUGAUCAGGCAGUGC… 668 nt 0.6662
NM_001346096.2 NCBI
GGGAUUUUGGAGUUGAGCACCAUGGGGACUCCAAAUGAUCAGGCAGUGC… 803 nt 0.6314
NM_001346097.2 NCBI
GGGAUUUUGGAGUUGAGCACCAUGGGGACUCCAAAUGAUCAGGCAGUGC… 780 nt 0.6372
Summary

The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016]

Forensic Context

A study in humans demonstrated that the TTC36 was downregulated in the subcutaneous adipose tissue of heavier monozygotic co-twins discordant for body mass index [Muniandy et al. DOI:10.1038/ijo.2017.95].