Basic Information

Symbol
TTK
RNA class
mRNA
Alias
TTK Protein Kinase MPS1L1 MPS1 CT96 MPH1 Phosphotyrosine Picked Threonine-Protein Kinase Dual Specificity Protein Kinase TTK Threonine And Tyrosine Kinase Monopolar Spindle 1 Kinase Cancer/Testis Antigen 96 PYT Phosphotyrosine Picked Threonine Kinase Monopolar Spindle 1-Like 1 EC 2.7.12.1 ESK
Location (GRCh38)
6:80003887-80043580
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003318.5
Sequence length
2966.0 nt
GC content
0.3641

Transcripts

ID Sequence Length GC content
NM_001166691.2 NCBI
CAAACGUGUUUGCGGAAAGGAGUUUGGGUUCCAUCUUUUCAUUUCCCCA… 2975 nt 0.3630
NM_003318.5 NCBI
CAAACGUGUUUGCGGAAAGGAGUUUGGGUUCCAUCUUUUCAUUUCCCCA… 2966 nt 0.3641
Summary

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Forensic Context

No relevant information is available at the moment.