Basic Information

Symbol
TTLL6
RNA class
mRNA
Alias
Tubulin Tyrosine Ligase Like 6 Tubulin Tyrosine Ligase-Like Family Member 6 Tubulin--Tyrosine Ligase-Like Protein 6 Tubulin Polyglutamylase TTLL6 Protein Polyglutamylase TTLL6 FLJ35808 TTL.6 EC 6.3.2.-
Location (GRCh38)
17:48762234-48817229
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001130918.3
Sequence length
3573.0 nt
GC content
0.5158

Transcripts

ID Sequence Length GC content
NM_001130918.3 NCBI
AGCGCCUGGGCGGUUAAUUGGAUUCGGGAGGGAGGGGGCAUGGCAGCUA… 3573 nt 0.5158
NM_001366314.2 NCBI
GGGGCUGUCUGGCAGCCAAUGGGAGCGUUACUCCUUCAUCCUUCGAGGA… 3393 nt 0.4960
NM_173623.4 NCBI
AUUUUUCCUUAGUCUAAGGGCACAGAAUGGAAAGGUUCUCAUUUUCCUC… 2549 nt 0.5128
Summary

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule bundle formation; protein polyglutamylation; and regulation of cilium beat frequency involved in ciliary motility. Predicted to act upstream of or within microtubule severing and positive regulation of cilium movement. Located in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the TTLL6 as a gene differentially expressed in the dorsolateral prefrontal cortex of individuals with alcohol use disorder and found it to be significantly associated with drinks per week in a genome-wide association study lookup [Willis et al. DOI:10.1038/S41380-024-02777-1].