Basic Information

Symbol
TUBB
RNA class
mRNA
Alias
Tubulin Beta Class I OK/SW-Cl.56 Tubb5 M40 Tubulin, Beta Polypeptide Tubulin Beta-5 Chain Tubulin Beta Chain MGC16435 Epididymis Secretory Sperm Binding Protein Tubulin, Beta Class I Class I Beta-Tubulin Tubulin Beta-1 Chain Beta Ib Tubulin Beta1-Tubulin Tubulin, Beta CDCBM6 CSCSC1 TUBB1 TUBB5
Location (GRCh38)
6:30717435-30725538
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mixture deconvolution
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_178014.4
Sequence length
2515.0 nt
GC content
0.5105

Transcripts

ID Sequence Length GC content
NM_001293212.2 NCBI
AGACCCCCAGCCUUUUGUGCGCCGCGCGGUGGGGCGGUGCCCAGCUUGG… 2661 nt 0.5239
NM_001293213.2 NCBI
CUCUCAGAACCUUCCUGCCGUCGCGUUUGCACCUCGCUGCUCCAGCCUC… 1909 nt 0.4924
NM_001293214.2 NCBI
CUCUCAGAACCUUCCUGCCGUCGCGUUUGCACCUCGCUGCUCCAGCCUC… 2383 nt 0.5065
NM_001293215.2 NCBI
AGACCCCCAGCCUUUUGUGCGCCGCGCGGUGGGGCGGUGCCCAGCUUGG… 2564 nt 0.5234
NM_001293216.2 NCBI
AGACCCCCAGCCUUUUGUGCGCCGCGCGGUGGGGCGGUGCCCAGCUUGG… 2463 nt 0.5201
NM_178014.4 NCBI
CUCUCAGAACCUUCCUGCCGUCGCGUUUGCACCUCGCUGCUCCAGCCUC… 2515 nt 0.5105
Summary

This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]

Forensic Context

A study in mice demonstrated that following clodronate pre-treatment and controlled cortical impact injury, a distinct neutrophil-like monocyte cluster (C9) emerged, characterized by upregulated expression of proliferative phenotype genes including the TUBB [Gudenschwager Basso et al. DOI:10.1186/s12974-024-03032-8]. The adoptive transfer of these monocytes from treated donors into injured recipient mice directly conferred neuroprotection, reducing lesion volume and improving cerebral blood flow. A study in humans demonstrated that the TUBB is a blood-specific mRNA marker selected as a candidate gene from microarray analysis [Park et al. DOI:10.1016/j.fsigen.2012.09.001]. A subsequent human study developed a massively parallel sequencing assay incorporating the TUBB among other genes, where it functioned as a blood-specific marker for both body fluid identification and donor association in complex mixtures, with the assay achieving a discriminatory power for blood of 0.99999999827 [Liu et al. DOI:10.1016/j.fsigen.2024.103066].