Basic Information

Symbol
TUBB2A
RNA class
mRNA
Alias
Tubulin Beta 2A Class IIa TUBB2 Class IIa Beta-Tubulin Tubulin Beta-2A Chain Tubulin, Beta 2A DJ40E16.7 TUBB Tubulin, Beta Polypeptide 2 Tubulin, Beta Polypeptide Tubulin Beta Class IIa Tubulin, Beta 2 CDCBM5
Location (GRCh38)
6:3153497-3157544
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001069.3
Sequence length
1616.0 nt
GC content
0.5928

Transcripts

ID Sequence Length GC content
NM_001069.3 NCBI
AGGUCUCUGCGCAGCCCAGCCCGCCGGUCCACGCCGCGCACCGCUCCGA… 1616 nt 0.5928
NM_001310315.2 NCBI
AGGUCUCUGCGCAGCCCAGCCCGCCGGUCCACGCCGCGCACCGCUCCGA… 1748 nt 0.5767
Summary

Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Forensic Context

A study in human trauma patients demonstrated that the TUBB2A mRNA was significantly downregulated in circulating CD3+ T cells during the injury stage compared to the recovery stage [Rau et al. DOI:10.2147/JIR.S375881].