Basic Information

Symbol
TUSC3
RNA class
mRNA
Alias
Tumor Suppressor Candidate 3 N33 Magnesium Uptake/Transporter TUSC3 SLC58A2 OST3A MagT2 MRT7 Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit TUSC3 Oligosaccharyl Transferase Subunit TUSC3 MGC13453 MRT22 Mental Retardation, Non-Syndromic, Autosomal Recessive, 22 Oligosaccharyltransferase 3 Homolog A (S. Cerevisiae) Putative Prostate Cancer Tumor Suppressor Oligosaccharyltransferase 3 Homolog A Protein N33 D8S1992 M33
Location (GRCh38)
8:15417215-15766649
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006765.4
Sequence length
3697.0 nt
GC content
0.3808

Transcripts

ID Sequence Length GC content
NM_001356429.2 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 3899 nt 0.4163
NM_001413583.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 5592 nt 0.3686
NM_001413669.1 NCBI
ACUAUCUUCCUCCUGCUCUGGCUGUGUGAAGAUCUGCCUCCUUCCUCUU… 4358 nt 0.3552
NM_001413670.1 NCBI
ACUAUCUUCCUCCUGCUCUGGCUGUGUGAAGAUCUGCCUCCUUCCUCUU… 4451 nt 0.3590
NM_001413671.1 NCBI
ACUAUCUUCCUCCUGCUCUGGCUGUGUGAAGAUCUGCCUCCUUCCUCUU… 4423 nt 0.3559
NM_001413672.1 NCBI
ACUAUCUUCCUCCUGCUCUGGCUGUGUGAAGAUCUGCCUCCUUCCUCUU… 4456 nt 0.3600
NM_001413673.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 1444 nt 0.4820
NM_001413674.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 4455 nt 0.3751
NM_001413675.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 2917 nt 0.4073
NM_001413676.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 4316 nt 0.3721
Showing 1 to 10 of 27 entries
Summary

This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the TUSC3 in microglia, where it is involved in the protein processing of endoplasmic reticulum pathway [Oladapo et al. DOI:10.3390/Ijms26020649].