Basic Information

Symbol
TUSC3
RNA class
mRNA
Alias
Tumor Suppressor Candidate 3 N33 Magnesium Uptake/Transporter TUSC3 SLC58A2 OST3A MagT2 MRT7 Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit TUSC3 Oligosaccharyl Transferase Subunit TUSC3 MGC13453 MRT22 Mental Retardation, Non-Syndromic, Autosomal Recessive, 22 Oligosaccharyltransferase 3 Homolog A (S. Cerevisiae) Putative Prostate Cancer Tumor Suppressor Oligosaccharyltransferase 3 Homolog A Protein N33 D8S1992 M33
Location (GRCh38)
8:15417215-15766649
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006765.4
Sequence length
3697.0 nt
GC content
0.3808

Transcripts

ID Sequence Length GC content
NM_001413687.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 1494 nt 0.4652
NM_001413688.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 1399 nt 0.4911
NM_001413689.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 4615 nt 0.3764
NM_001413690.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 4540 nt 0.3756
NM_001413691.1 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 1284 nt 0.4883
NM_006765.4 NCBI
AGUCUCCUCCUCUGCGUCCUCGGCCGCGGCCCGGGUCCCUCGCAAAGCC… 3697 nt 0.3808
NM_178234.2 NCBI
AGAUUGAGGUCCCAGGGCCAAAGGACCACUCCUCUCCUCAGCGCUGGUC… 3823 nt 0.3950
Showing 21 to 27 of 27 entries
Summary

This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the TUSC3 in microglia, where it is involved in the protein processing of endoplasmic reticulum pathway [Oladapo et al. DOI:10.3390/Ijms26020649].