Basic Information

Symbol
TXK
RNA class
mRNA
Alias
TXK Tyrosine Kinase RLK PSCTK5 BTKL PTK4 TKL PTK4 Protein Tyrosine Kinase 4 Tyrosine-Protein Kinase TXK Protein-Tyrosine Kinase 4 Resting Lymphocyte Kinase EC 2.7.10.2 EC 2.7.10
Location (GRCh38)
4:48063158-48134250
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003328.3
Sequence length
2908.0 nt
GC content
0.4051

Transcripts

ID Sequence Length GC content
NM_003328.3 NCBI
AGUUGAAAGAUGUGUUUUUGUGAGUAGAGCACCGCAGAAGAACUGAAGA… 2908 nt 0.4051
Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of macromolecule biosynthetic process; positive regulation of type II interferon-mediated signaling pathway; and protein autophosphorylation. Located in cytosol; nuclear lumen; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the TXK mRNA was downregulated in ante-mortem burned skin compared to control tissue [Liu et al. DOI:10.1007/s12024-022-00474-5].