Basic Information

Symbol
TXN
RNA class
mRNA
Alias
Thioredoxin TRX Trx80 TXN1 Surface-Associated Sulphydryl Protein ATL-Derived Factor TRDX TRX1 SASP ADF Testicular Tissue Protein Li 199 Thioredoxin Delta 3 Allergen Hom S Trx TXN Delta 3 Trx
Location (GRCh38)
9:110243810-110256604
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003329.4
Sequence length
737.0 nt
GC content
0.3677

Transcripts

ID Sequence Length GC content
NM_001244938.2 NCBI
GAAGCUCUGUUUGGUGCUUUGGAUCCAUUUCCAUCGGUCCUUACAGCCG… 677 nt 0.3634
NM_003329.4 NCBI
GAAGCUCUGUUUGGUGCUUUGGAUCCAUUUCCAUCGGUCCUUACAGCCG… 737 nt 0.3677
Summary

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in mice demonstrated that the TXN was significantly upregulated in a caecal ligation and puncture-induced sepsis model, with increased protein and mRNA expression levels confirmed by Western blot and RT-qPCR [Tao et al. DOI:10.1007/s10753-025-02346-w]. In human studies, the TXN was identified as a diagnostic biomarker upregulated in sepsis patients through transcriptomic and single-cell RNA sequencing analyses, showing predominant expression in monocytes and other immune cells and strong diagnostic performance in ROC curve analyses [Lu et al. DOI:10.3389/fimmu.2025.1543517].