Basic Information

Symbol
TXN2
RNA class
mRNA
Alias
Thioredoxin 2 MT-TRX Thioredoxin, Mitochondrial MTRX TRX2 Mitochondrial Thioredoxin Thioredoxin-2 COXPD29 Mt-Trx TXN
Location (GRCh38)
22:36466895-36482072
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012473.4
Sequence length
1336.0 nt
GC content
0.5636

Transcripts

ID Sequence Length GC content
NM_012473.4 NCBI
GAGGAAGUGACGACAGGCGUGCCCUUGACAGGCAGGGAGGGCUAGGCUG… 1336 nt 0.5636
Summary

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the TXN2 was significantly upregulated in a caecal ligation and puncture-induced sepsis model, with increased protein and mRNA expression levels confirmed by Western blot and RT-qPCR [Tao et al. DOI:10.1007/s10753-025-02346-w]. In human studies, the TXN2 was identified as a key diagnostic biomarker upregulated in sepsis patients through transcriptomic and single-cell RNA sequencing analyses, showing predominant expression in monocytes and other immune cells and strong diagnostic performance in ROC curve analyses [Lu et al. DOI:10.3389/fimmu.2025.1543517].