Basic Information

Symbol
TYK2
RNA class
mRNA
Alias
Tyrosine Kinase 2 JTK1 Non-Receptor Tyrosine-Protein Kinase TYK2 EC 2.7.10.2 EC 2.7.10 IMD35
Location (GRCh38)
19:10350528-10380608
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003331.5
Sequence length
4243.0 nt
GC content
0.6140

Transcripts

ID Sequence Length GC content
NM_001385197.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4132 nt 0.6159
NM_001385198.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4093 nt 0.6145
NM_001385199.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 3967 nt 0.6163
NM_001385200.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4240 nt 0.6142
NM_001385201.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4045 nt 0.6136
NM_001385202.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4159 nt 0.6124
NM_001385203.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4324 nt 0.6136
NM_001385204.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4453 nt 0.6122
NM_001385205.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4153 nt 0.6126
NM_001385206.1 NCBI
AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… 4117 nt 0.6123
Showing 1 to 10 of 13 entries
Summary

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020] CIViC Summary for TYK2 Gene

Forensic Context

No relevant information is available at the moment.