Basic Information
Symbol
TYK2
RNA class
mRNA
Alias
Tyrosine Kinase 2
JTK1
Non-Receptor Tyrosine-Protein Kinase TYK2
EC 2.7.10.2
EC 2.7.10
IMD35
Location (GRCh38)
19:10350528-10380608
Forensic tag(s)
-
MANE select
Transcript ID
NM_003331.5
Sequence length
4243.0 nt
GC content
0.6140
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… | 4225 nt | 0.6137 | |
| AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… | 4153 nt | 0.6179 | |
| AAGCAGUAGCUACCCGCGGGAGCGGGGAGGGGUCCGGGUUCGAGCUUGU… | 4243 nt | 0.6140 |
Showing 11 to 13 of 13 entries
Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020] CIViC Summary for TYK2 Gene
Forensic Context
No relevant information is available at the moment.