Basic Information

Symbol
TYMP
RNA class
mRNA
Alias
Thymidine Phosphorylase Gliostatin ECGF1 EC 2.4.2.4 TdRPase MNGIE TP Endothelial Cell Growth Factor 1 (Platelet-Derived) Platelet-Derived Endothelial Cell Growth Factor HPD-ECGF EC 2.4.2 PD-ECGF MEDPS1 MTDPS1 PDECGF ECGF
Location (GRCh38)
22:50525752-50530326
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001953.5
Sequence length
1586.0 nt
GC content
0.6942

Transcripts

ID Sequence Length GC content
NM_001113755.3 NCBI
AGUGGACCGCUGUGCGCGAACCCUGAACCCUACGGUCCCGACCCGCGGG… 1598 nt 0.6946
NM_001113756.3 NCBI
AGUGGACCGCUGUGCGCGAACCCUGAACCCUACGGUCCCGACCCGCGGG… 1770 nt 0.6966
NM_001257988.1 NCBI
CGACUGCCGAGCUCCGCCCUCCAGGCGGCCCCACCCGCCUGCCGUCCUG… 1718 nt 0.6927
NM_001257989.1 NCBI
CGACUGCCGAGCUCCGCCCUCCAGGCGGCCCCACCCGCCUGCCGUCCUG… 1682 nt 0.6992
NM_001953.5 NCBI
AGUGGACCGCUGUGCGCGAACCCUGAACCCUACGGUCCCGACCCGCGGG… 1586 nt 0.6942
Summary

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]

Forensic Context

A study in rats demonstrated that the TYMP mRNA was up-regulated in whole brains in a blast intensity- and time-dependent manner following blast wave exposure, correlating with histological evidence of vascular injury and thrombosis [Balaban et al. DOI:10.1016/j.jneumeth.2016.02.001]. A study in mice demonstrated that the TYMP mRNA was significantly increased in magnetically isolated CD31+ endothelial cells from juvenile injured cortices compared to adult injured cortices following controlled cortical impact [Brickler et al. DOI:10.1523/JNEUROSCI.0914-18.2018].