Basic Information

Symbol
TYRO3
RNA class
mRNA
Alias
TYRO3 Protein Tyrosine Kinase Etk-2 Dtk Tif Sky Rek RSE Tyrosine-Protein Kinase Receptor TYRO3 Tyrosine-Protein Kinase DTK Tyrosine-Protein Kinase RSE Tyrosine-Protein Kinase SKY Tyrosine-Protein Kinase TIF EC 2.7.10.1 Brt BYK Tyrosine-Protein Kinase Byk Tyrosine-Protein Kinase BYK EC 2.7.10 DTK SKY TIF
Location (GRCh38)
15:41557675-41583589
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006293.4
Sequence length
8032.0 nt
GC content
0.5244

Transcripts

ID Sequence Length GC content
NM_001330264.2 NCBI
GAGGCAUUUGCUGGUGACAAGAGCGUUCCAUGCAGCACGGUGCUCUCCA… 8187 nt 0.5214
NM_006293.4 NCBI
CUCCUCGCUCGCGGGCCGGGCCCGGCAUGGUGCGGCGUCGCCGCCGAUG… 8032 nt 0.5244
Summary

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

Forensic Context

A study in porcine skin demonstrated that cutaneous bromine exposure significantly decreased the expression of the TYRO3 gene across all experimental groups (45-second and 8-minute exposures at 24 hours and 7 days post-exposure) [Price et al. DOI:10.1016/j.toxlet.2008.08.007].