Basic Information

Symbol
TYSND1
RNA class
mRNA
Alias
Trypsin Like Peroxisomal Matrix Peptidase 1 NET41 Peroxisomal Leader Peptide-Processing Protease Peroxisome Leader Peptide-Processing Protease Trypsin Domain-Containing Protein 1 Peroxisomal Cysteine Endopeptidase Trypsin Domain Containing 1 MGC34695 Peroxisomal Matrix Protein–Processing Protease Peroxisomal Matrix Protein-Processing Protease EC 3.4.21.-
Location (GRCh38)
10:70137981-70146700
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_173555.4
Sequence length
3758.0 nt
GC content
0.6094

Transcripts

ID Sequence Length GC content
NM_001040273.3 NCBI
CUCUCGCUUCCAGCUGUGGGUGGCGCUAGGCAGCUUCAGCCGGACCGGG… 3441 nt 0.6097
NM_173555.4 NCBI
CUCUCGCUUCCAGCUGUGGGUGGCGCUAGGCAGCUUCAGCCGGACCGGG… 3758 nt 0.6094
Summary

This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Forensic Context

A study in humans demonstrated that in monozygotic twin pairs discordant for body mass index, the gene TYSND1 was upregulated in the skeletal muscle of heavier co-twins, where it was linked to lipid metabolism [van der Kolk et al. DOI:10.1016/j.xcrm.2021.100226].