Basic Information

Symbol
U2AF2
RNA class
mRNA
Alias
U2 Small Nuclear RNA Auxiliary Factor 2 U2AF65 U2 SnRNP Auxiliary Factor Large Subunit U2 Small Nuclear Ribonucleoprotein Auxiliary Factor (65kD) U2 (RNU2) Small Nuclear RNA Auxiliary Factor 2 Splicing Factor U2AF 65 KDa Subunit U2 Auxiliary Factor 65 KDa Subunit HU2AF65 Splicing Factor U2AF 65 KD Subunit HU2AF(65) DEVDFB
Location (GRCh38)
19:55654146-55674716
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007279.3
Sequence length
2146.0 nt
GC content
0.6048

Transcripts

ID Sequence Length GC content
NM_001012478.2 NCBI
AGCCGAAGCGGCUGGAGCGGGCGGCAAGGCGAGGCGAAAGCUGCACAGG… 2134 nt 0.6036
NM_007279.3 NCBI
AGCCGAAGCGGCUGGAGCGGGCGGCAAGGCGAGGCGAAAGCUGCACAGG… 2146 nt 0.6048
Summary

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the protein U2af2 (U2 small nuclear RNA auxiliary factor 2) was identified as a potential target of the U2AF2 in primary cardiomyocytes, where its protein level was downregulated following transfection with a miR-483-3p mimic, though this effect was not statistically significant [Xue et al. DOI:10.1161/JAHA.122.026160].