Basic Information

Symbol
UBA52
RNA class
mRNA
Alias
Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 CEP52 HUBCEP52 RPL40 L40 Ubiquitin-Ribosomal Protein EL40 Fusion Protein Ubiquitin Carboxyl Extension Protein 52 Ubiquitin-52 Amino Acid Fusion Protein Ubiquitin-CEP52 MGC126879 MGC126881 MGC57125 Ubiquitin-60S Ribosomal Protein L40 60S Ribosomal Protein L40 Ribosomal Protein L40 UBCEP2
Location (GRCh38)
19:18571730-18577550
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001033930.3
Sequence length
2848.0 nt
GC content
0.5098

Transcripts

ID Sequence Length GC content
NM_001033930.3 NCBI
CUUCUUUUUCUUCAGCGAGGCGGCCGAGCUGGUUGGUGGCGGCGGUCGU… 2848 nt 0.5098
NM_001321017.2 NCBI
GGCUUCGUUCGCCAGCAUCCAAGAUGGCGGCAGGGCGGGGCCCAAGGCG… 2908 nt 0.5144
NM_001321018.2 NCBI
CUUCUUUUUCUUCAGCGAGGCGGCCGAGCUGGUUGGUGGCGGCGGUCGU… 3546 nt 0.5245
NM_001321019.2 NCBI
CUUCUUUUUCUUCAGCGAGGCGGCCGAGCUGGUUGGUGGCGGCGGUCGU… 3084 nt 0.5282
NM_001321020.2 NCBI
CUUCUUUUUCUUCAGCGAGGCGGCCGAGCUGGUUGGUGGCGGCGGUCGU… 3118 nt 0.5289
NM_001321021.1 NCBI
GGGGAUGGCUUCCCAUCCAGGCUGGCAGCAGGAGCAGCCUGUGCAGAUC… 2838 nt 0.5092
NM_001321022.2 NCBI
CUUCUUUUUCUUCAGCGAGGCGGCCGAGCUGGUUGGUGGCGGCGGUCGU… 2761 nt 0.5089
NM_003333.5 NCBI
CUUCUUUUUCUUCAGCGAGGCGGCCGAGCUGACGCAAACAUGCAGAUCU… 2826 nt 0.5078
Summary

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]

Forensic Context

A longitudinal mRNA expression analysis in human post-mortem blood samples demonstrated that the UBA52 shows an up-regulated expression pattern after death and is involved in nucleotide-excision repair, specifically in DNA damage recognition and DNA duplex unwinding, as part of active processes promoting cell survival and DNA damage repair [Antiga et al. DOI:10.1038/s41598-021-96095-z]. This gene was identified as a top hub gene with upregulated expression in human sepsis patients, showing a logFC of 9.94, and was validated as having good diagnostic value for sepsis in independent GEO datasets [Yu et al. DOI:10.1016/j.heliyon.2023.e15034].