Basic Information

Symbol
UBE2B
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 B HHR6B RAD6B UBC2 Ubiquitin-Conjugating Enzyme E2B (RAD6 Homolog) Ubiquitin-Conjugating Enzyme E2-17 KDa Ubiquitin-Conjugating Enzyme E2 B E2 Ubiquitin-Conjugating Enzyme B Ubiquitin Carrier Protein B Ubiquitin-Protein Ligase B RAD6 Homolog B HR6B Ubiquitin-Conjugating Enzyme E2B Ubiquitin Conjugating Enzyme E2B EC 2.3.2.23 EC 6.3.2.19 E2 Protein E2-17kDa UBCH1
Location (GRCh38)
5:134371184-134393959
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003337.4
Sequence length
2241.0 nt
GC content
0.3637

Transcripts

ID Sequence Length GC content
NM_003337.4 NCBI
AGACUGACCGCGGGGCAGCUGCGGAGCAUGUCGACCCCGGCCCGGAGGA… 2241 nt 0.3637
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the UBE2B in microglia, as part of a broad disruption of the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649].