Basic Information

Symbol
UBE2D1
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 D1 UBCH5 Stimulator Of Fe Transport E2(17)KB1 UbcH5A UBC4/5 SFT Ubiquitin-Conjugating Enzyme E2D 1 (UBC4/5 Homolog, Yeast) (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D1 Ubiquitin-Conjugating Enzyme E2-17 KDa 1 Ubiquitin-Conjugating Enzyme E2(17)KB 1 Ubiquitin-Conjugating Enzyme E2 D1 E2 Ubiquitin-Conjugating Enzyme D1 Ubiquitin Carrier Protein D1 Ubiquitin-Protein Ligase D1 UBC4/5 Homolog Ubiquitin-Conjugating Enzyme E2D 1 Ubiquitin Conjugating Enzyme E2D 1 EC 2.3.2.23 EC 2.3.2.24 EC 6.3.2.19 UBCH5A UBC5A UbcH5
Location (GRCh38)
10:58334975-58370751
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003338.5
Sequence length
2623.0 nt
GC content
0.3363

Transcripts

ID Sequence Length GC content
NM_001204880.2 NCBI
GCACACUCGCGCACACUCGCGCUCGGGCGCACACGGAGCAGGGACCGGC… 2591 nt 0.3338
NM_003338.5 NCBI
GCACACUCGCGCACACUCGCGCUCGGGCGCACACGGAGCAGGGACCGGC… 2623 nt 0.3363
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the UBE2D1 in cortical microglia, affecting both the ubiquitin-mediated proteolysis and protein processing of endoplasmic reticulum pathways [Oladapo et al. DOI:10.3390/Ijms26020649].