Basic Information

Symbol
UBE2D4
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 D4 HBUCE1 Ubiquitin-Conjugating Enzyme E2 D4 E2 Ubiquitin-Conjugating Enzyme D4 Ubiquitin Carrier Protein D4 Ubiquitin-Protein Ligase D4 Ubiquitin-Conjugating Enzyme E2D 4 (Putative) Ubiquitin Conjugating Enzyme E2 D4 (Putative) Ubiquitin Conjugating Enzyme E2D 4 (Putative) Ubiquitin-Conjugating Enzyme HBUCE1 EC 2.3.2.23 EC 6.3.2.19 UBCH5D
Location (GRCh38)
7:43926436-43956136
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_015983.4
Sequence length
3982.0 nt
GC content
0.4789

Transcripts

ID Sequence Length GC content
NM_015983.4 NCBI
GCGGCUCCCGGCGUGCAGCUUGGUGGCGGCUGAGCCGGCAGCGGGCCGC… 3982 nt 0.4789
Summary

Enables ubiquitin conjugating enzyme activity. Involved in protein polyubiquitination. Acts upstream of or within protein ubiquitination. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the UBE2D4 as one of six key cuproptosis-related diagnostic biomarkers for sepsis, where it demonstrated the highest AUC (0.911) among the signature and its expression was validated in a separate cohort, with single-cell RNA-seq showing its major distribution in monocytes, T cells, B cells, and NK cells in sepsis samples [Wang et al. DOI:10.1016/j.heliyon.2024.e27379]. In a separate human study on weight loss, the UBE2D4 was found to be downregulated in subcutaneous adipose tissue during short-term weight loss in obese participants [Bollepalli et al. DOI:10.1038/ijo.2017.245].