Basic Information

Symbol
UBE2E3
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 E3 UbcH9 Ubiquitin-Conjugating Enzyme E2E 3 (Homologous To Yeast UBC4/5) Ubiquitin-Conjugating Enzyme E2E 3 (UBC4/5 Homolog, Yeast) Ubiquitin-Conjugating Enzyme E2-23 KDa Ubiquitin-Conjugating Enzyme E2 E3 E2 Ubiquitin-Conjugating Enzyme E3 Ubiquitin Carrier Protein E3 Ubiquitin-Protein Ligase E3 Ubiquitin-Conjugating Enzyme E2E 3 Ubiquitin Conjugating Enzyme E2E 3 EC 2.3.2.23 EC 6.3.2.19 UbcM2 UBCE4 UBCH9
Location (GRCh38)
2:180967248-181076585
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006357.4
Sequence length
1555.0 nt
GC content
0.4868

Transcripts

ID Sequence Length GC content
NM_001278554.2 NCBI
GUUCGCGCCGGGCGCCCGCGUCGCCGGUGUCCGCGAGCCGCGGCGGGGC… 1606 nt 0.4682
NM_001278555.2 NCBI
GGCACAGGCUCCGCGGCCAAGGGCGGCAGGGGCCAGCCCGCCGGGUCCC… 1373 nt 0.4690
NM_006357.4 NCBI
GGAACUUGCUGACUGCGCGGCCGGGAGGAGCCGAGCCGGGCGGCGGCGG… 1555 nt 0.4868
NM_182678.3 NCBI
GGCACAGGCUCCGCGGCCAAGGGCGGCAGGGGCCAGCCCGCCGGGUCCC… 1405 nt 0.4797
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

Forensic Context

A study in mice demonstrated that the UBE2E3 was upregulated in common in white blood cells at day 1 post-injury following both burn and trauma-hemorrhage, where it was categorized as a gene expression marker associated with the cell death pathway [Lederer et al. DOI:10.1152/physiolgenomics.00086.2007].