Basic Information

Symbol
UBE2G2
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 G2 UBC7 Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7) Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast) Ubiquitin-Conjugating Enzyme E2 G2 E2 Ubiquitin-Conjugating Enzyme G2 Ubiquitin Carrier Protein G2 Ubiquitin-Protein Ligase G2 Ubiquitin-Conjugating Enzyme E2G 2 Ubiquitin Conjugating Enzyme G2 Ubiquitin Conjugating Enzyme 7 EC 2.3.2.23 EC 6.3.2.19
Location (GRCh38)
21:44768580-44801826
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003343.6
Sequence length
3367.0 nt
GC content
0.4930

Transcripts

ID Sequence Length GC content
NM_001202489.2 NCBI
AGUCCCCGGUGUCGGGGCAGGAGGCACGCGCGCGGCUGAGGCGAGGUCG… 3285 nt 0.4950
NM_003343.6 NCBI
AGUCCCCGGUGUCGGGGCAGGAGGCACGCGCGCGGCUGAGGCGAGGUCG… 3367 nt 0.4930
NM_182688.3 NCBI
AGUCCCCGGUGUCGGGGCAGGAGGCACGCGCGCGGCUGAGGCGAGGUCG… 3482 nt 0.4934
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the UBE2G2 in cortical microglia, where it is involved in the ubiquitin-mediated proteolysis and protein processing of endoplasmic reticulum pathways [Oladapo et al. DOI:10.3390/Ijms26020649].