Basic Information

Symbol
UBE2H
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 H UBCH UBC8 GID3 Ubiquitin-Conjugating Enzyme E2H (UBC8 Homolog, Yeast) (E3-Independent) E2 Ubiquitin-Conjugating Enzyme H Ubiquitin-Conjugating Enzyme E2-20K Ubiquitin-Conjugating Enzyme E2 H E2 Ubiquitin-Conjugating Enzyme H Ubiquitin Carrier Protein H Ubiquitin-Protein Ligase H Ubiquitin-Conjugating Enzyme E2H (Homologous To Yeast UBC8) GID Complex Subunit 3, UBC8 Homolog (S. Cerevisiae) GID Complex Subunit 3, UBC8 Homolog Ubiquitin Conjugating Enzyme E2H EC 2.3.2.23 EC 2.3.2.24 EC 6.3.2.19 E2-20K UBCH2 UbcH2
Location (GRCh38)
7:129830732-129952977
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003344.4
Sequence length
5162.0 nt
GC content
0.4653

Transcripts

ID Sequence Length GC content
NM_001202498.2 NCBI
AGAGCGAGGCUGGGGUAGGGAGGCCGACUGAGCAGGAGUCGUCCGCUUA… 4783 nt 0.4409
NM_003344.4 NCBI
AGAGCGAGGCUGGGGUAGGGAGGCCGACUGAGCAGGAGUCGUCCGCUUA… 5162 nt 0.4653
NM_182697.3 NCBI
AGAGCGAGGCUGGGGUAGGGAGGCCGACUGAGCAGGAGUCGUCCGCUUA… 5069 nt 0.4672
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the ubiquitin-mediated proteolysis pathway in cortical microglia, with the UBE2H being one of many ubiquitin-conjugating enzymes affected [Oladapo et al. DOI:10.3390/Ijms26020649].