Basic Information

Symbol
UBE2I
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 I UBC9 Ubiquitin-Conjugating Enzyme E2I (Homologous To Yeast UBC9) Ubiquitin-Conjugating Enzyme E2I (UBC9 Homolog, Yeast) RING-Type E3 SUMO Transferase UBC9 SUMO-Conjugating Enzyme UBC9 Ubiquitin Carrier Protein 9 Ubiquitin Carrier Protein I Ubiquitin-Protein Ligase I SUMO-Protein Ligase P18 Ubiquitin-Like Protein SUMO-1 Conjugating Enzyme Ubiquitin-Conjugating Enzyme UbcE2A Ubiquitin-Conjugating Enzyme E2 I Ubiquitin-Conjugating Enzyme E2I Ubiquitin Conjugating Enzyme E2I Ubiquitin Conjugating Enzyme 9 Ubiquitin-Protein Ligase E2I SUMO-1-Protein Ligase EC 2.3.2.- C358B7.1 EC 6.3.2 UBCE9
Location (GRCh38)
16:1291357-1327018
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003345.5
Sequence length
2850.0 nt
GC content
0.5568

Transcripts

ID Sequence Length GC content
NM_003345.5 NCBI
AGGGUCCUCGGAGCUGCUCUGGCUGCGCGCGGAGCGGGCUCCGGAGGGA… 2850 nt 0.5568
NM_194259.3 NCBI
AGGGUCCUCGGAGCUGCUCUGGCUGCGCGCGGAGCGGGCUCCGGAGGGA… 3107 nt 0.5613
NM_194260.3 NCBI
GAACUCGCGGGAGCGUCACCGUCCUGCGACGCUUCAGAGGAUCCUUAGG… 2980 nt 0.5560
NM_194261.3 NCBI
GAACUCGCGGGAGCGUCACCGUCCUGCGACGCUUCAGAGGAUCCUUAGG… 2832 nt 0.5505
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the UBE2I in microglia, implicating it within the ubiquitin-mediated proteolysis pathway as part of the broader methamphetamine-induced transcriptomic changes in glial cells [Oladapo et al. DOI:10.3390/Ijms26020649].