Basic Information

Symbol
UBE2J1
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 J1 NCUBE1 HSPC153 CGI-76 UBC6 Ubiquitin-Conjugating Enzyme E2, J1 (UBC6 Homolog, Yeast) Yeast Ubiquitin-Conjugating Enzyme UBC6 Homolog E Non-Canonical Ubiquitin-Conjugating Enzyme 1 Ubiquitin-Conjugating Enzyme E2 J1 E2 Ubiquitin-Conjugating Enzyme J1 NCUBE-1 Ubiquitin-Conjugating Enzyme E2, J1, U Ubiquitin-Conjugating Enzyme E2, J1 EC 2.3.2.23 HSU93243 HSPC205 HSUBC6e HsUBC6e UBC6E Ubc6p
Location (GRCh38)
6:89326608-89352902
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016021.3
Sequence length
4164.0 nt
GC content
0.3886

Transcripts

ID Sequence Length GC content
NM_016021.3 NCBI
ACCCCGCCCGCAGUCCAGGCUGGACUGGGCGGCAUUUGCCGAGGCUCCU… 4164 nt 0.3886
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the UBE2J1 in cortical microglia, where it is involved in the ubiquitin-mediated proteolysis and protein processing of endoplasmic reticulum pathways [Oladapo et al. DOI:10.3390/Ijms26020649].