Basic Information

Symbol
UBE2J2
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 J2 NCUBE2 Ubiquitin-Conjugating Enzyme E2, J2 (UBC6 Homolog, Yeast) Non-Canonical Ubiquitin-Conjugating Enzyme 2 Ubiquitin-Conjugating Enzyme E2 J2 E2 Ubiquitin-Conjugating Enzyme J2 NCUBE-2 Ubc6p Ubiquitin-Conjugating Enzyme E2, J2 Ubiquitin Conjugating Enzyme 6 Yeast UBC6 Homolog EC 2.3.2.23 EC 6.3.2.19 PRO2121 UBC6
Location (GRCh38)
1:1253907-1274477
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_058167.3
Sequence length
2260.0 nt
GC content
0.5951

Transcripts

ID Sequence Length GC content
NM_058167.3 NCBI
GGUUCCGCCCCGCGAGCGGCCAUCUUGGAGGCUGAGGCGGCGGCGGCGG… 2260 nt 0.5951
NM_194315.2 NCBI
GGUUCCGCCCCGCGAGCGGCCAUCUUGGAGGCUGAGGCGGCGGCGGCGG… 2308 nt 0.5940
NM_194457.2 NCBI
GGUUCCGCCCCGCGAGCGGCCAUCUUGGAGGCUGAGGCGGCGGCGGCGG… 2129 nt 0.5970
NM_194458.2 NCBI
GGUUCCGCCCCGCGAGCGGCCAUCUUGGAGGCUGAGGCGGCGGCGGCGG… 2389 nt 0.6015
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the UBE2J2 was upregulated in elderly patients with high total body surface area burn injuries, as identified through microarray analysis of blood leukocytes during the acute post-burn phase [Dreckmann et al. DOI:10.1371/journal.pone.0226425].