Basic Information

Symbol
UBE2L3
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 L3 UBCH7 Ubiquitin-Conjugating Enzyme E2 L3 E2 Ubiquitin-Conjugating Enzyme L3 Ubiquitin-Conjugating Enzyme E2-F1 Ubiquitin Carrier Protein L3 Ubiquitin-Protein Ligase L3 L-UBC Ubiquitin-Conjugating Enzyme E2L 3 Ubiquitin Conjugating Enzyme E2L 3 Ubiquitin-Conjugating Enzyme UBCH7 EC 2.3.2.23 EC 6.3.2.19 E2-F1 UbcM4 UBCE7 UbcH7
Location (GRCh38)
22:21549447-21624034
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003347.4
Sequence length
2861.0 nt
GC content
0.4974

Transcripts

ID Sequence Length GC content
NM_001256355.1 NCBI
AGUAUGCAGGUCGCUGCAGGGACCCGAGGCGACACGCGCCUGCAGGAGG… 3007 nt 0.5098
NM_001256356.2 NCBI
AUUCUGGGGAAGGAGCAGCACCAAAUCCAAGAUGGCGGCCAGCAGGAGG… 2765 nt 0.5005
NM_003347.4 NCBI
AUUCUGGGGAAGGAGCAGCACCAAAUCCAAGAUGGCGGCCAGCAGGAGG… 2861 nt 0.4974
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the UBE2L3 in cortical microglia, as part of widespread disruptions to ubiquitin-mediated proteolysis, autophagy, and mitophagy pathways revealed by single-cell RNA sequencing [Oladapo et al. DOI:10.3390/Ijms26020649]. A study in human postmortem brain tissue demonstrated that the UBE2L3 is up-regulated in both the frontal and motor cortices of alcoholic cases compared to controls, as identified through cDNA microarray profiling and validated by Bayesian statistical analysis and hierarchical clustering [Liu et al. DOI:10.1111/J.1471-4159.2004.02570.X]. Separately, research on degraded forensic samples established that targeting transcript stable regions (StaRs) with specifically designed primers enables the consistent and specific detection of RNA biomarkers, including related ubiquitin-conjugating enzymes, across various degraded body fluids for identification purposes [Lin et al. DOI:10.1016/j.fsigen.2015.09.012].