Basic Information

Symbol
UBE2M
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 M UBC12 HUbc12 Ubiquitin-Conjugating Enzyme E2M (UBC12 Homolog, Yeast) NEDD8-Conjugating Enzyme Ubc12 NEDD8 Carrier Protein Ubiquitin-Conjugating Enzyme E2M (Homologous To Yeast UBC12) Epididymis Secretory Sperm Binding Protein Ubiquitin-Conjugating Enzyme E2 M Ubiquitin-Conjugating Enzyme E2M Ubiquitin Conjugating Enzyme E2M Ubiquitin Carrier Protein M Ubiquitin-Protein Ligase M NEDD8 Protein Ligase Yeast UBC12 Homolog EC 2.3.2.34 EC 6.3.2 UBC-RS2
Location (GRCh38)
19:58555709-58558954
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003969.4
Sequence length
1159.0 nt
GC content
0.6324

Transcripts

ID Sequence Length GC content
NM_003969.4 NCBI
GAGUCCGAGGCGCUGGGCCAGGCCGGAGCCGGACUACGGGAGCCGAGGC… 1159 nt 0.6324
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the UBE2M in cortical microglia, as part of a broad disruption of ubiquitin-mediated proteolysis pathways [Oladapo et al. DOI:10.3390/Ijms26020649].