Basic Information
Symbol
UBE2O
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 O
E2-230K
(E3-Independent) E2 Ubiquitin-Conjugating Enzyme
E2/E3 Hybrid Ubiquitin-Protein Ligase UBE2O
Ubiquitin-Conjugating Enzyme E2 Of 230 KDa
Ubiquitin-Conjugating Enzyme E2-230K
Ubiquitin Carrier Protein O
Ubiquitin-Protein Ligase O
Ubiquitin-Conjugating Enzyme E2 O
Ubiquitin-Conjugating Enzyme E2O
Ubiquitin Conjugating Enzyme E2O
EC 2.3.2.24
KIAA1734
Location (GRCh38)
17:76389456-76453208
Forensic tag(s)
Sudden cardiac death diagnosis
MANE select
Transcript ID
NM_022066.4
Sequence length
5377.0 nt
GC content
0.5832
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GCAGAGCAGUUAUGGCGGAUCCCGCAGCCCCCACGCCCGCAGCUCCCGC… | 5377 nt | 0.5832 |
Summary
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in rhesus macaques identified the UBE2O as a differentially expressed gene downregulated in left ventricular tissue from animals with hypertrophic cardiomyopathy compared to healthy controls [Rivas et al. DOI:10.1038/s41598-024-82770-4].