Basic Information

Symbol
UBE2W
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 W UBC-16 N-Terminal E2 Ubiquitin-Conjugating Enzyme E2 Ubiquitin-Conjugating Enzyme W Ubiquitin-Conjugating Enzyme 16 Ubiquitin Carrier Protein W Ubiquitin-Protein Ligase W N-Terminus-Conjugating E2 Ubiquitin Conjugating Enzyme E2 W (Putative) Ubiquitin-Conjugating Enzyme E2 W FLJ11011 UBC16 Ubiquitin-Conjugating Enzyme E2W (Putative) Ubiquitin Conjugating Enzyme E2W (Putative) Ubiquitin-Conjugating Enzyme 2W EC 2.3.2.23 EC 2.3.2.25 EC 6.3.2.19
Location (GRCh38)
8:73780097-73878910
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018299.6
Sequence length
8379.0 nt
GC content
0.3453

Transcripts

ID Sequence Length GC content
NM_001001481.4 NCBI
GCGUCUCUGGCCUCGCCGGUCUUGGGGGGAUGGUUCCAUCAUGGCGUCA… 8412 nt 0.3459
NM_001271015.3 NCBI
GCGUCUCUGGCCUCGCCGGUCUUGGGGGGAUGGUUCCAUCAUGGCGUCA… 904 nt 0.4237
NM_018299.6 NCBI
GCGUCUCUGGCCUCGCCGGUCUUGGGGGGAUGGUUCCAUCAUGGCGUCA… 8379 nt 0.3453
Summary

This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates numerous genes in cortical glial cells, including the UBE2W which was significantly dysregulated in microglia as part of the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649].