Basic Information

Symbol
UBE2Z
RNA class
mRNA
Alias
Ubiquitin Conjugating Enzyme E2 Z USE1 Uba6-Specific E2 Conjugating Enzyme 1 Ubiquitin-Conjugating Enzyme E2 Z E2 Ubiquitin-Conjugating Enzyme Z Ubiquitin Carrier Protein Z Ubiquitin-Protein Ligase Z UBA6-Specific Enzyme E2 FLJ13855 Ubiquitin-Conjugating Enzyme E2Z Ubiquitin Conjugating Enzyme E2Z EC 2.3.2.23 EC 6.3.2.19 HOYS7 Use1
Location (GRCh38)
17:48908398-48929056
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_023079.5
Sequence length
3084.0 nt
GC content
0.5324

Transcripts

ID Sequence Length GC content
NM_023079.5 NCBI
ACUCUGGCCCGGUUCUCGGUGGUGCGGGAGCGGGCGGGAGCAGCGGCCG… 3084 nt 0.5324
Summary

This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the UBE2Z in cortical microglia, as part of widespread disruptions to ubiquitin-mediated proteolysis and autophagy pathways [Oladapo et al. DOI:10.3390/Ijms26020649].