Basic Information

Symbol
UBE3C
RNA class
mRNA
Alias
Ubiquitin Protein Ligase E3C KIAA0010 KIAA10 Homologous To E6AP Carboxyl Terminus Homologous Protein 2 HECT-Type Ubiquitin Transferase E3C RTA-Associated Ubiquitin Ligase Ubiquitin-Protein Ligase E3C RAUL Ubiquitin-Protein Isopeptide Ligase (E3) EC 2.3.2.26 NEDSMBA HECTH2 NDSMBA HectH2
Location (GRCh38)
7:157138922-157269372
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014671.3
Sequence length
5214.0 nt
GC content
0.4730

Transcripts

ID Sequence Length GC content
NM_014671.3 NCBI
GCACGCACUGACGGCUGACCGCCAUCUUCCCUCCCGAGGCGGCAGUUCC… 5214 nt 0.4730
Summary

Enables ubiquitin protein ligase activity. Involved in protein K29-linked ubiquitination; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the UBE3C in cortical microglia, as part of a broad disruption of the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649].