Basic Information

Symbol
UBE3D
RNA class
mRNA
Alias
Ubiquitin Protein Ligase E3D H10BH C6orf157 YJR141W UBE2CBP Ubiquitin-Conjugating Enzyme E2C-Binding Protein UBCH10 Binding Protein With A Hect-Like Domain UbcH10-Binding Protein With A HECT-Like Domain HECT-Type E3 Ubiquitin Transferase E3D E3 Ubiquitin-Protein Ligase E3D DKFZp434A1520 Ubiquitin-Conjugating Enzyme E2C Binding Protein Chromosome 6 Open Reading Frame 157 EC 2.3.2.26
Location (GRCh38)
6:82892390-83065841
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_198920.3
Sequence length
1925.0 nt
GC content
0.4457

Transcripts

ID Sequence Length GC content
NM_001304437.2 NCBI
ACAGGCGCCUGCGCCGCAGCGGGGCUGCCGCUGGUUGGUCCGCACGUGG… 1887 nt 0.4409
NM_001350602.2 NCBI
ACAGGCGCCUGCGCCGCAGCGGGGCUGCCGCUGGUUGGUCCGCACGUGG… 2018 nt 0.4485
NM_001350603.2 NCBI
ACAGGCGCCUGCGCCGCAGCGGGGCUGCCGCUGGUUGGUCCGCACGUGG… 1834 nt 0.4493
NM_001350604.2 NCBI
ACAGGCGCCUGCGCCGCAGCGGGGCUGCCGCUGGUUGGUCCGCACGUGG… 1989 nt 0.4490
NM_001410933.1 NCBI
ACAGGCGCCUGCGCCGCAGCGGGGCUGCCGCUGGUUGGUCCGCACGUGG… 2902 nt 0.3853
NM_198920.3 NCBI
ACAGGCGCCUGCGCCGCAGCGGGGCUGCCGCUGGUUGGUCCGCACGUGG… 1925 nt 0.4457
Summary

Enables cyclin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in protein autoubiquitination; protein monoubiquitination; and protein polyubiquitination. Part of ubiquitin ligase complex. Is active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in rats demonstrated that the UBE3D was significantly upregulated in the orbitofrontal cortex of both male and female rats after heroin self-administration [Floris et al. DOI:10.3390/ijms23031453].