Basic Information

Symbol
UBE4A
RNA class
mRNA
Alias
Ubiquitination Factor E4A KIAA0126 UBOX2 UFD2 E4 Ubiquitination Factor E4A (UFD2 Homolog, Yeast) RING-Type E3 Ubiquitin Transferase E4 A Ubiquitin Conjugation Factor E4 A Ubiquitination Factor E4A (Homologous To Yeast UFD2) EC 2.3.2.27 NEDHMS
Location (GRCh38)
11:118359587-118399211
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001204077.2
Sequence length
6088.0 nt
GC content
0.4129

Transcripts

ID Sequence Length GC content
NM_001204077.2 NCBI
GUGCUGAGUCGGAAGUGGGAACCCUUCGGCCGCUGAGAUUCUGUCGUGU… 6088 nt 0.4129
NM_004788.4 NCBI
GUGCUGAGUCGGAAGUGGGAACCCUUCGGCCGCUGAGAUUCUGUCGUGU… 6109 nt 0.4128
Summary

This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the UBE4A in cortical microglia, where it is involved in ubiquitin-mediated proteolysis and protein processing of endoplasmic reticulum pathways [Oladapo et al. DOI:10.3390/Ijms26020649].