Basic Information

Symbol
UBE4B
RNA class
mRNA
Alias
Ubiquitination Factor E4B UFD2 KIAA0684 UBOX3 E4 Ubiquitination Factor E4B (UFD2 Homolog, Yeast) RING-Type E3 Ubiquitin Transferase E4 B Ubiquitin Conjugation Factor E4 B HDNB1 Ubiquitination Factor E4B (Homologous To Yeast UFD2) Homozygously Deleted In Neuroblastoma-1 Homozygously Deleted In Neuroblastoma 1 Ubiquitin-Fusion Degradation Protein 2 Ubiquitin Fusion Degradation Protein 2 Homologous To Yeast UFD2 EC 2.3.2.27 UFD2A
Location (GRCh38)
1:10032832-10181244
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001105562.3
Sequence length
5905.0 nt
GC content
0.4923

Transcripts

ID Sequence Length GC content
NM_001105562.3 NCBI
CCCUUUCAAAGAUGGCCGCCCUGUUGUUUUGAUGAAUAAUACUUGGUGG… 5905 nt 0.4923
NM_001410744.1 NCBI
CCCUUUCAAAGAUGGCCGCCCUGUUGUUUUGAUGAAUAAUACUUGGUGG… 6058 nt 0.4913
NM_006048.5 NCBI
CCCUUUCAAAGAUGGCCGCCCUGUUGUUUUGAUGAAUAAUACUUGGUGG… 5518 nt 0.4817
Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the UBE4B in microglia, where it is involved in both ubiquitin-mediated proteolysis and protein processing of endoplasmic reticulum pathways [Oladapo et al. DOI:10.3390/Ijms26020649].